Sr. Scientist – Protein Engineering:
Merck USA

Merck USA
Rahway New Jersey
Requisition ID: CHE005840

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 

Highly motivated scientists are being sought to join the Protein Engineering group in the Department of Biochemical Engineering & Structure.  The group works out of the Rahway, NJ site and multiple opportunities are available.   Successful candidates will join a group of innovative scientists with broad deliverables ranging from evolved enzymes for biocatalytic implementation in drug manufacturing routes to the delivery of optimized protein scaffolds to enable discovery.  These are scientific positions that require critical thinking, flexibility, multitasking, and the ability to bring in new technologies to enable rapid design, generation, and testing of engineered proteins.  



  • M.S. with a minimum of 4 years experience OR Ph.D. with a minimum of 1 year Post doc in Molecular Biology, Biochemistry or related field.


  • Experience in directed evolution / engineering of proteins
  • Proficient in current molecular biology and recombinant protein production technologies  
  • Experience with DNA sequencing technologies (Sanger & NGS) and processing software such as Vector NTI, Sequencher, or equivalent
  • Demonstrated ability to work within a collaborative multi-disciplinary team environment
  • Strong written and oral communication skills 
  • Strong organizational skills and demonstrated ability to multi-task


  • Experience with high-throughput screening and automated liquid handling
  • Experience with the engineering of proteins to enable incorporation of unnatural amino acids 
  • Knowledge of biocatalysis
  • Experience characterizing the biophysical properties of proteins via SDS-PAGE, Western Blot, spectrophotometric assays, and SEC-HPLC
  • Experience using analytical instrumentation such as UPLC, HPLC, LC-MS, and GC  
  • Good grasp of organic chemical principles and comfort with the use of organic chemicals
  • Demonstrated ability to generate novel ideas and concepts

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. 


If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to [email protected].


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Job: Chemistry
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Employee Status: Regular
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Company Trade Name: Merck
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