Description
Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas' PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas' pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: ARV-110 and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.
#TeamArvinas is made up of more than 300 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company's values and purpose - to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It's an exciting time to be in drug development and it's an exciting time to be at Arvinas. But don't just take our word for it - here's what Arvinas employees are saying . For more information, please visit .
Position Summary
We have an exciting opportunity to join our cell biology team! As an experienced scientist, you will be an important part of a highly motivated and matrixed team within the Platform Biology group at Arvinas. This position will be dedicated to conducting experiments and screens to develop PROTAC molecules. This position will use quantitative cell-based methods to characterize target engagement of compounds for transformation into PROTACs, to profile PROTAC molecules, and for cell-based compound library screening.
This is a committed bench scientist position, reports to the Research Investigator in our Platform Biology group, and will be located at our headquarters in New Haven, CT.
Principal Responsibilities
Key responsibilities of this role include, but are not limited to:
- Development and characterization of cell-based assay systems to query targeted protein degradation (molecular biology, stable cell line generation, Western blots, ELISA, reporter assays, etc.).
- Development and optimization of quantitative cell-based assays using a variety of readout technologies (e.g., fluorescence, luminescence, BRET) in medium- to high-throughput (96/384-well) formats.
- Cell-based compound library screening.
- Partner with diverse project teams in complex scheduling of work and generation of data in support of drug discovery and development programs. Troubleshoot through technical and scientific challenges in order to deliver critical data.
- Apply excellent organizational and prioritization skills; analyze data using strong background in quantitative cell biological sciences.
- Organize experimental results to be shared with project teams; openly communicate with chemistry and biology; maintain clear experimental records.
- Leverage knowledge of the ubiquitin-proteasome system and emerging principles of targeted protein degradation.
Qualifications
- Independent, motivated, and productive problem solver with excellent communication skills who works effectively in a team setting.
- Strength in experimental design, execution, and data analysis using multiple assay platforms.
- Proficiency in aseptic mammalian cell/tissue culture is a must.
- Experience in molecular biology techniques: plasmid and cell line engineering
- Experience in generating CRISPR/Cas9-mediated KO or KI cell lines is a plus.
- Experience measuring protein levels: western blot, ELISA, reporter assays, etc.
- Experience in utilizing compounds and molecular target manipulation (e.g., RNAi, CRISPR) to dissect target function and dependency.
- Experience in design, QC, and execution of medium- to high- throughput (96/384-well) cell-based assay formats, such as ELISA, quantitative Western, High Content Imaging, bioluminescent, and/or fluorescence-based assays
- Expertise in cell biology and biochemistry
- Knowledge and understanding of the ubiquitin-proteasome system is a plus.
- Knowledge of drug discovery approaches is a plus.
- Organized, goal-oriented and timeline-conscious.
- Other Preferred Skills and Knowledge
- Maintaining clear experimental records
- Organize and clearly present experimental results to the project team(s)
- Experience with Microsoft Excel, Prism; data analysis using Spotfire would be a plus.
- A strong work ethic and willingness for continued learning.
Education
- B.S. with 12+ years experience, M.S. with 6+ years experience, or Ph.D. with 2+ years experience (including postdoc). Pharma or biotech experience in cellular and molecular biology, cell-based assays, or pharmacology or Ph.D. with an excellent publication record demonstrating productivity in cell-based and biochemical research.
Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit
Arvinas is an Equal Opportunity employer
