Description
Senior Research Associate, Downstream Process Development
Affinia Therapeutics is an innovative gene therapy company focused on broadening the reach of gene therapy. Our proprietary Affinia Rationally-designed Therapies (ART) platform is created to address key limitations of conventional gene therapies, by developing novel capsids, novel promoters, and novel manufacturing approaches to developing gene therapies for rare and prevalent devastating diseases. We are backed by a strong syndicate of life science investors and have ambitious plans to have a dramatic impact on the lives of patients around the world.
As an early employee you will play a key role in setting our culture and values. You will be working alongside the founding management team who have a track record of success in the industry. The pace of work is dynamic, fast and fun. We offer competitive salary and benefits with the ability to make a difference.
Position Summary
Establish Affinia as a leader in AAV process development through the application of processes, procedures and technologies for best-in-class manufacturing platforms. This position reports to the Associate Director, Process Development and will dedicate efforts downstream process development activities to establish state of the art AAV processes.
Primary Responsibilities
- Design, plan, and execute experiments related to development, optimization, scale-up, and characterization in viral vector purification processes
- Hands-on experience with purification unit operations including harvest, clarification/filtration, chromatography, TFF, etc
- Apply DOE and other advanced statistical techniques to design experiments
- Review technical documents, including study protocols, study reports, batch records, SOPs, etc. to ensure process readiness for in-house and CDMO production activities
- Contribute in a team-oriented environment to achieve common project goals
Minimum Qualifications
- BS. with 2+ years' Industry experience, or Master's degree with 0+ years' Industry experience. A degree in biochemical engineering, chemical engineering, biochemistry or related.
Preferred Qualifications
- Process development experience for gene therapies/biologics is highly preferred including a solid understanding of fundamentals of process development
- Experience in bench-scale, pilot-scale, and/or production-scale biomanufacturing.
- Excellent organization, verbal and written communication, and presentation skills.
- Proven troubleshooting, technical writing, problem solving and investigational skills
EEO Statement: Affinia Therapeutics is proud to be an equal opportunity workplace. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.
