Description
Career Category Scientific
Job Description HOW MIGHT YOU DEFY IMAGINATION?
If you feel like you're part of something bigger, it's because you are. At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies. We are global collaborators who achieve together-researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It's time for a career you can be proud of. Join us.
Senior Principal Scientist - Targeted Protein Degradation - E3 Ligase Biology Group Leader
Live What you will do
Let's do this. Let's change the world. In this vital role you will be apart of our Induced Proximity Platform (IPP) leading our E3 ubiquitin ligase biology group in Thousand Oaks, California. The IPP is charged with developing Amgen's newest drug modality aimed at Targeted Protein Degradation, including discovery of PROTACs and molecular GLUEs.
- You will be a key strategic partner in the IPP responsible for coordinating cross-functional activities.
- Responsible for leading a multidisciplinary team to support early discovery of Targeted Protein Degradation drugs, including the characterization of E3 ubiquitin ligases.
- The ideal candidate will have broad laboratory training, deep scientific curiosity and a positive approach to working in a team-based research environment along with a track record of creative problem-solving and enthusiasm for taking on difficult research challenges.
- Deep understanding of ubiquitin ligases and the ubiquitin-proteasome system is essential. This group will be primarily cell and molecular biology focused.
Win What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The Scientific professional we seek is a versatile leader with these qualifications.
Basic qualifications - Doctorate Degree with 6 years of protein degradation and E3 ubiquitin ligase biology experience
- Master's degree and 10 years of protein degradation and E3 ubiquitin ligase biology experience
- Bachelor's degree and 15 years of protein degradation and E3 ubiquitin ligase biology experience
Preferred qualifications - Demonstrated ability to lead an independent group of scientists
- Broad knowledge of protein degradation and E3 ubiquitin ligase biology with demonstrated independent research eminence through first and senior author publications in top journals
- Specific expertise and a record of publication in the biology and biochemistry of E3 ubiquitin ligases.
- Research experience with biochemical, biophysical, molecular and cellular techniques, including enzyme and cell assay development, characterization of protein modification and turnover, and mechanistic studies of enzymes
- Strong written/verbal communication and interpersonal skills
- Demonstrated scientific analysis and problem-solving skills as evidenced in peer review publications.
- Desire to be a team player in a dynamic, cross-functional environment
- Experience in drug discovery, particularly in regard to Targeted Protein Degradation strategies
Thrive What you can expect of us
As we work to develop treatments that take care of others, so we work to care for our teammates' professional and personal growth and well-being.
- Vast opportunities to learn and move up and across our global organization
- Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
- Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits
Apply now for a career that defies imagination
In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us.
careers.amgen.com .
