Description
The Position
We are seeking a talented Scientist/Senior Scientist to join the Biochemical and Cellular Pharmacology Department at Genentech. The successful candidate will be part of a dynamic and highly motivated team driving the characterization of large molecule drug candidates that are being developed for various diseases in the neuroscience therapeutic area.
Responsibilities
You will be responsible for the development, optimization and execution of functional pharmacology assays especially utilizing complex cellular or engineered organoid/tissue models to support our protein therapeutic discovery programs for the selection and advancement of lead molecules. This position requires working with multidisciplinary teams, including biology team members from Discovery Research, as well as with Antibody Engineering, Protein Chemistry, Structural Biology, Pharmacokinetics and Safety Assessment. You are expected to represent Biochemical and Cellular Pharmacology on project teams and contribute at the bench as well as at strategic levels. A strong candidate will be enthusiastic about supporting the operation of a dynamic laboratory, have great attention to detail and superior organizational skills. Working with automation and bioinformatics experts, the individual will be expected to implement robust and high throughput sample preparation as well as data analysis workflows. You will have the opportunity to design and execute complex screening cascades for multiple projects, conduct detailed data analyses and present these to project teams and senior management.
Requirements:
* Ph.D. in molecular and cellular biology, neuroscience or a related field and candidates with at least 3 or more years of relevant post-doctoral experience will be considered for Senior Scientist.
* Deep knowledge and hands on experience with human embryonic or induced pluripotent stem cells (hPSCs). Differentiation of hPSCs to various cell types for the aim of disease modeling and drug discovery.
* Demonstrate experience with CRISPR gene editing in hPSCs.
* Extensive experience in utilizing confocal microscopy, and high-content imaging for developing complex cell-based assays.
* Ability to adopt and leverage rapidly advancing, new technologies to promote strategic aims.
* Excellent teamwork, communication, time management, organization skills and ability to work independently.
* Focus on quantitative methods to drive results, and demonstrate resilience and persistence in their experimental approach
* Familiarity with automated or semi-automated instrumentation, while not required, would be advantageous, as would familiarity with the multi-disciplinary activities of antibody lead profiling
* Strong record of high-profile publications
Preferred:
* Experience with in vitro drug screening.
* Proficiency with differentiation of hPSCs to neurons, astrocytes and microglia.
* Experience with hPSC derived complex 3D brain organoids models in drug discovery.
* Previous pharmaceutical/biotech experience in relevant models.
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Who We Are
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
The next step is yours. To apply today, click on the "Apply online" button.
Genentech is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status. For more information about equal employment opportunity, visit our Genentech Careers page.
Relocation benefits are available for this job posting.
Who we are
A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
Unless entitled to a reasonable accommodation under applicable law, employees are required to be fully vaccinated against COVID-19 in accordance with customer requirements, the company's health and safety obligations and/or applicable law or guidelines.
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.
Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. For more information about equal employment opportunity, visit our Genentech Careers Homepage.
Job Level:
Individual contributor
