Description
NGM Biopharmaceuticals, Inc., a biotechnology company focused on discovering and developing novel, life-changing medicines for people whose health and lives have been disrupted by disease, is a leader in the emerging area of immuno-oncology R&D known as myeloid checkpoint inhibition. We have built a comprehensive myeloid reprogramming and checkpoint inhibition portfolio with three disclosed product candidates targeting four receptors - ILT2, ILT3, ILT4 and LAIR1 - engineered to reprogram myeloid cells to reverse the suppression of immune responses to tumor cells. In addition, we are developing an antagonist antibody designed to inhibit GFRAL discovered as a result of our research into metabolism and autonomic nervous system regulation of the immune system. These product candidates are the fruits of our biology-centric drug discovery approach, which aims to seamlessly integrate interrogation of complex disease-associated biology and protein engineering expertise to unlock proprietary insights that are leveraged to generate promising product candidates and enable their rapid advancement into proof-of-concept studies. As explorers on the frontier of life-changing science, we aspire to operate one of the most productive research and development engines in the biopharmaceutical industry and our research team has a track record of producing an average of one new IND candidate per year. Today the company has seven disclosed programs, including four in Phase 2 or 2b studies, across three therapeutic areas: cancer, retinal diseases, and liver and metabolic diseases.
We are seeking a highly motivated PhD-level scientist to join the Immuno-Oncology Translational Science team. The scientist in this role will act as a Translational Science Lead for an NGM immune-oncology clinical program and will be responsible for the overall biomarker strategy for the program. The individual will perform in-house analysis of clinical trial samples and will oversee the analysis of biomarker data generated by contract research organizations or other members of the NGM Translational Science team. In collaboration with other Translational scientists, the scientist in this role will conduct research to identify novel pharmacodynamic or predictive biomarkers and will develop strategies to implement testing of these biomarkers within the clinical trial plan. The individual will also collaborate with other Translational scientists to conduct research addressing mechanisms contributing to anti-tumor activity. This position requires working in close collaboration across departments, including Clinical Science, Clinical Operations, Clinical Pharmacology, Bioanalytical, Regulatory, CMC, and other groups within Translational Research to manage sample collection and inventory, provide input on biomarker assays developed by other Translational Science teams (e.g., Pathology or Bioinformatics), and provide input to guide indication and dose selection.
Key Responsibilities
* Oversee the management, organization, and use of clinical trial samples received at NGM
* Act as a "point person" to communicate the status of biomarker assays to the relevant project team(s)
* Ensuring internal and external biomarker data is delivered within program timelines
* Perform hands-on analysis of clinical trial samples using techniques such as Luminex or qRT-PCR
* Manage relationships with external vendors implementing biomarker assays
* Perform research related to biomarker discovery and mechanism of action, incorporating both in-house and published research findings
* Develop and implement new biomarker assays to assess both peripheral and tumor-associated immune responses
Required Skills
* Deep knowledge of biomarker discovery and development, including assay development and validation for both tissue-associated and soluble biomarkers
* Knowledge of techniques used in immune-oncology biomarker analysis, including multi-parameter flow cytometry and RNA expression analysis
* Strong verbal and written communication skills
* Ability to work effectively and collaboratively on cross-functional teams
* Experience with mouse models of immuno-oncology, including drug dosing and tissue collection, is highly desirable but not required
Required Experience
* PhD in immunology, oncology, or a related biological/biomedical field
* Postdoctoral training and 0-3+ years industry experience (title will be commensurate with experience)
* Prior experience related to biomarkers for cancer immunotherapy is highly desirable
We will consider candidate preference for an onsite or hybrid work schedule
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