Description
About Earli
The mission of Earli is large and ambitious: make cancer a benign experience.
Earli is developing a new orthogonal approach for early cancer detection and localization, making the disease actionable a stage when the chances of survival are significantly higher. Rather than rely on naturally shed biomarkers that cancer may or may not provide, Earli's platform technology usurps the dysregulated pathways that cause malignancy and *forces* cancer cells to make a synthetic, non-human biomarker using gene therapy approaches. It's called a Synthetic Biopsy . It can then localize the cancer in a PET scanner, and even be extended to therapeutics. Developed initially by the late Sam Gambhir , former head of Stanford's Canary Center for Early Cancer Detection, and co-founded by serial entrepreneur Cyriac Roeding and gene therapy veteran David Suhy , Earli is funded by Andreessen Horowitz's Bio Fund, Khosla Ventures, Perceptive Advisors, Casdin Capital, Sands Capital, Marc Benioff, Menlo Ventures and ZhenFund. Earli is based in the West Coast's prime biotech hub in South San Francisco. Earli's scientific advisors include Jim Allison (MD Anderson, Nobel Laureate), Pam Sharma (MD Anderson), Bob Langer (MIT, Moderna), Phil Greenberg (Fred Hutchinson Cancer Research Center), Lee Hartwell (formerly Fred Hutchinson Cancer Research Center, Nobel Laureate), Alan Ashworth (UCSF) and Judy Garber (Dana-Farber).
Who You Are
- You share our same sense of dedication, scientific passion and entrepreneurial spirit
- You work well in a fast-paced and extremely focused startup environment
- You are not only smart, but clever and constantly think outside the box
- You are able to make logical decisions in an instant when there is little time to evaluate
- You are a natural communicator and relationship builder
- You stay calm under high pressure and stress
- You have the ability to multi-task in a serious way, with an extreme attention to detail
- You become a representative of the core DNA of the company through who you are
Your Primary Responsibilities
Earli, Inc. is currently seeking motivated In Vivo Biology Scientist. She/he will be responsible for the implementing preclinical in vivostudies to characterize Earli's proprietary compounds from discovery through to IND enabling studies.
- Conduct high quality in vivo studies independently and work with cross-functional teams to design in vivo studies
- Develop and characterize in vivo model systems and technologies to evaluate efficacy of novel test compounds in a variety of animal models (i.e. CDX, PDX, metastatic, orthotopic, benign and transgenic/GEMM models)
- Analyze, interpret, and communicate scientific data to team members in a timely manner
- Present scientific findings at team and staff meetings
Your Required Experience, Knowledge and Skill
- BS or MS degree in biological science, animal science, cancer biology or a related discipline with at least 7+ years of hands-on in vivo experience or PhD with 0-2 years of relevant experience.
- Excellent dosing skills (IV, IP, PO, SC, IM, intratracheal, etc) and bleeding skills (submandibular bleed, cardiac puncture, etc.)
- Excellent tissue harvest and necropsy skills
- Excellent survival surgical skills, particularly with orthotopic and tumor resection models
- Experience in developing tumor and non-tumor in vivo model systems including PDX models
- Experience with different analytical methods (i.e. FACS, ELISA, etc.)
- Experience with different in vivo imaging modalities, such as an optical imager and CT imager.
- Excellent analytical and record keeping skills.
- Adept in designing animal studies, and drafting study protocols and reports
- Excellent verbal communication and interpersonal skills
- Must be able to multi-task, manage multiple projects simultaneously with minimal error, and work effectively within a team
- Must be able to think independently and fully integrate into a high achieving team environment.
If interested in applying, please attach a CV or have a well-developed LinkedIn profile for us to be able to assess your background.
We look forward to hearing from you!
