Description
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Job Description About the role:
At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Join Takeda as a Research Principal Scientist where you will support innovative preclinical oncology programs across immunomodulation, adaptive immunity, and small molecule inhibitor strategies. You will lead a team to develop studies that identify preclinical mechanisms of action, pharmacodynamic markers, and predictive biomarker signatures through tissue-based testing and image analysis.. As part of the Precision & Translational Medicine group, you will report to Darrell Borger, Director of Translational Sciences.
How you will contribute:
- Embed within program teams to help shape investigative strategies and serve as a subject matter expert on histology/tissue-based testing.
- Provide an important role in developing a continuum between preclinical testing and clinical trial evaluation through the development of clinically-relevant biomarkers and testing strategies that serve to improve patient benefit.
- Work within our Cold-To-Hot program teams to develop investigative strategies that serve to identify key mechanistic and translational questions throughout preclinical stages of drug development.
- Lead a team of 3-5 laboratory scientists in the development of tissue-based assays (IHC,RNA ISH, mIF), execution of investigational studies, and data analysis through image informatics (HALO software).
- Manage the development of innovative tissue-based testing platforms with technology collaborators.
- Work with our clinical biomarker and companion diagnostics teams to provide a strategy of further developing our research use only assays toward clinical tests.
- Design, implement, and delver research testing that identify mechanism of action, pharmacodynamic markers, and biodistribution signatures.
- Present results in an interactive format that facilitates discussion and planning of future development directions.
- Work with human preclinical modelling groups and use human biorepository specimens to conduct leading experiments that identify translational biomarkers for clinical implementation.
Minimum Requirements/Qualifications:
- PhD, or internationally recognized equivalent degree, in a medical/biological science.
- 6 years experience in an academic or pharmaceutical setting.
- Demonstrated research expertise through past/ongoing grant support, first/last-authored manuscript publications in cancer biology, and/or invited scientific presentations.
- Knowledge of cancer biology and its relationship to treatment effects and strategies.
- Working knowledge of tissue-based testing platforms (IHC, RNA ISH, mIF).
What Takeda can offer you:
- Comprehensive Healthcare: Medical, Dental, and Vision
- Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan
- Health & Wellness programs including onsite flu shots and health screenings
- Generous time off for vacation and the option to purchase additional vacation days
- Community Outreach Programs and company match of charitable contributions
- Family Planning Support
- Flexible Work Paths
- Tuition reimbursement
More about us:
At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.
Absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. US field-based employees must be fully vaccinated as a condition of employment, absent an approved religious or medical reason. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. If you are contacted by a Takeda recruiter about your job application, we encourage you to seek more information on the applicable guidelines for the Business Unit/Function to which you have applied.
EEO Statement
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations Boston, MA
Worker Type Employee
Worker Sub-Type Regular
Time Type Full time
