Description
Parvus Therapeutics is pioneering a breakthrough class of disease-specific, non-immunosuppressive biologics called NavacimsTM that are designed to halt and potentially cure autoimmune disease and other inflammatory disorders by restoring immune tolerance. The Navacim technology platform is generating a rich pipeline of therapeutic candidates to address a wide range of inflammatory diseases. Our most advanced programs target Type 1 Diabetes (T1D) (partnered with Novartis) and autoimmune liver diseases. POC and efficacy in animals has been established not only for these two programs but also for multiple sclerosis (MS) and inflammatory bowel disease (IBD).
Parvus is seeking a Research Associate/Senior Research Associate with expertise in protein expression and purification to join the Parvus Biologics Research Group to conduct experiments enabling the development of Navacims towards clinical evaluation, as well as research and discovery effort fostering the Parvus product pipeline growth.
Responsibilities and duties include (but not limited to):
- Conduct protein expression and purification from mg to gram scale
- Contribute proactively to cross functional activities across Research groups and with other departments as needed.
- Document experiments/write study reports according to company protocols
- Present data at internal meetings
- Participate in all aspects of laboratory operation and organization
- Comply with employees and environmental safety company guidelines
- Other duties and responsibilities as assigned
Required Skills/Experience:
- BA/BS/Master degree in life sciences or equivalent with relevant experience in expression and purification of proteins/biologics in a Biotech/Pharma environment (2 years for Research Associate and 6 years for Senior Research Associate).
- Strong hands-on experience in small scale (shake flask) to 20L scale (Wave bioreactors) protein expression using transient expression/stable cell lines, harvesting culture using depth filtration/TFF and purification using GE Akta system (protein A, IMAC, IEX, HIC, SEC etc.).
- Expertise in large scale protein expression in Wave bioreactors and/or protein production cell line development (CHO) highly desirable
- Independently troubleshoot data and propose novel approaches or corrective experimental designs
- Creative while performing in a collaborative manner according to corporate objectives
- Hands-on self-starter with excellent technical and communication skills
- Organized and detail oriented, possessing excellent record-keeping skills
- Able to work in a fast-pace environment and adapt to changes under short notice with a proactive attitude.
This is a full-time, onsite position based in South San Francisco
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