Res Post Doc Fellow - Genomics of Neurodegenerative Traits:

Philadelphia Pennsylvania

LOC_ABRAMSON-Abramson Building Req ID: 76242

Shift: Days

Employment Status: Regular - Full Time 

Job Summary

A Postdoctoral Fellow is needed to join a dynamic group of investigators interested in studying the functional consequences of signals that have come out of recent genome wide association studies (GWAS) of Alzheimer's diseases and other neurodegenerative disorders. The successful candidate will be dedicated and motivated, and a driver of her/his research. The postdoctoral fellow will be responsible of setting up disease models in human cell lines and iPSC-derived neural cells, characterize their Alzheimer's related phenotypes and manipulate candidate gene expression using CRISPR/Cas9 and/or siRNA or gene overexpression, with the goal of validating novel Alzheimer's disease target genes. We are looking for a candidate with strong molecular biology skills (immunofluorescence, Western Blot, PCR, cloning) and prior experience in either cellular models of neurodegeneration or iPSC-derived neural cells biology. In addition, experience in CRISPR/Cas9 genome editing and next-generation sequencing based techniques (RNA-seq, ATAC-seq, ChIP-seq) would be a plus.

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Preffered Applicant:

A terminal degree PhD, MD, DVM with a major in biology, chemistry, biochemistry or related field preferred. Excellent communication, organizational and molecular biology skills are a must, together with previous experience either in cellular models of Alzheimer's disease / neurodegeneration or iPSC-derived neural cells. Hands-on experience with CRISPR/Cas9 genome editing and next-generation sequencing based techniques (such as RNA-seq, ATAC-seq, ChIP-seq) would be a plus.

Interested individuals should submit their resume to or Struan Grant, Ph.D., Abramson Research Center, The Children's Hospital of Philadelphia, Room 1216F, 3615 Civic Center Blvd., Philadelphia, PA 19104, [email protected]


Job Responsibilities
  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects
Required Licenses, Certifications, Registrations
Required Education and Experience
  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
Preferred Education, Experience & Cert/Lic
Additional Technical Requirements

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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CHOP Careers Contact 

Talent Acquisition

2716 South Street, 6th Floor

Philadelphia, PA 19146 

Phone: 866-820-9288 

Email:[email protected]



Basic Qualifications