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Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine?
At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver
Better Health and a Brighter Future to people around the world.
Here, you will be a vital contributor to our inspiring, bold mission.
Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
OBJECTIVES/PURPOSE The Cell Engager team of the Oncology DDU is looking for a and experienced Immunologist or cellular biologist to join a very collaborative and dynamic team to help advance the cell engager pipeline programs. You will manage the evaluation of various cell engager molecules linked to the COBRA platform and beyond to assess T and innate cell functional responses and differentiation. You will focus on the development of strategies, preclinical assays and screens that provide framework for evaluating various dysfunctional states of cytotoxic T cells particularly in solid tumors. You should have in-depth knowledge of T cell Biology and immune dysfunctional mechanisms in the tumor microenvironment to evaluate potential mechanisms of resistance of Immune cell engagers. You should have a strong foundation in redirected T cell immunity and hands-on experience in their evaluation in pre-clinical in vitro systems and experience with IO drug discovery. You should have project leadership experience working with cross functional teams and the ability to move candidates through lead selection. As an essential member of the team, you will be responsible for new idea generation, assessing therapeutic concepts and strategy of various immune engager molecules and advancing novel research molecules towards development candidates and IND. The position will require you to be hands-on, working closely and mentoring direct reports. You will collaborate and demonstrate effective communication and documentation of results with key stakeholders in IOI, C2H, Global Biologics, DSRE, DMPK, Translational teams and CTI.
ACCOUNTABILITIES - Design, lead and execute complex in vitro cell based assays to validate target specific biology and advance therapeutic cell engager programs working in close co-ordination with in vivo, Global biologics, DMPK
- Lead therapeutic T cell re-targeting programs from target validation through to candidate selection, and into Phase 1 clinical trials.
- Contribute to new idea generation and prioritization of tumor antigen selection
- Identify and integrate technologies that improve or expand the ability to assess the MoA of novel immunomodulatory agents
- Lead in vitro characterization design of MoR assays as it may pertain to T cell function in the TME by collaborating closely with Translational leads.
- Design and conduct in vitro cell based assays including target tumor antigen expression, T cell immunophenotyping, T cell dependent cytotoxicity and cytokine release as part of exvivo assessments.
- Immunophenotyping and gene profiling experiments using a variety of techniques including but not limited to mRNA profiling, multicolor flow cytometry etc.
- Build relationships with external research collaborators and CROs for cell based and translational assays a required
- Execute experiments with independence and deliver comprehensive high quality data sets to enable decision making
- Identify state of the art experimental protocols and relevant IO models and assays
- Keep up with published literature centered around cancer targets and IO therapies relevant to the Takeda's CE strategy
- Identify, plans and execute well defined scientific projects and communicate program strategy and timelines to management.
- Utilizes relevant information, technology and resources, contributing to complex team problem resolution and objectives
- Lead from the bench by providing guidance and mentoring to junior scientists
- Contribute to the writing of relevant research reports to be included in regulatory filings.
- Interpret results of complex experiments
- Prepares and presents comprehensive technical or project reports and formal presentations / posters to full range of internal/external audiences
- Maintain laboratory notebooks and keep in compliance with Takeda policies
DIMENSIONS AND ASPECTS Technical/Functional (Line) Expertise- Demonstrate theoretical knowledge of cell engager platforms
- Keep current with latest trends in immune cell engagers for application in cancer therapy
- Able to clarify requests and provide suggestions and put data into context especially in context of assay design and quality of data
- Demonstrates in-depth technical knowledge within various assay development platforms
Leadership- Indecently investigate new immunological techniques, that can be applied to team projects
- Serve as the in vitro immunobiology lead on projects providing essential scientific feedback to advance programs in a matrixed environment.
Decision-making and Autonomy- Independently manage own workload
- Scientifically independent
- Provide information to project teams to influence direction, align with departmental goals and business
Interaction- Conduct scientific presentations to internal audiences
- Collaborate with others across sites, and acts as scientific resource for in vitro pharmacology
- Participates in and supervises external interactions and collaborations with companies and academic research groups and potential collaborator
Innovation- Expected to participate in new target identification / validation process
- Strive towards expanding scientific knowledge in immunology
- Receive high level instructions on work; determine methods on new assignments; demonstrated greater independence; may manage interns
EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS: - PhD 10+ years, MS with 14+ BS with 16+ years experience (industry experience preferred), Cellular Immunology, Immuno-oncology, T cell biology
- Current knowledge of oncology research, drug discovery and development with an emphasis on immune cell activation, T cell retargeting platforms, protocols as well as markers for anti-tumor efficacy
- Proficient in the isolation, culture, and functional characterization of primary human immune cells.
- Experienced with multiparameter FACS and its application in measuring T cell activation, proliferation, cytokine production and identification of immune cell subsets
- Have experience with standard molecular biology techniques (PCR, Gibson assembly, cloning etc), ELISA, MSD and other standard cell based and non-cell based biochemical assays
- Experience with biologics is a must (Antibodies, ADCs, Cell therapies etc)
- Experience leading projects and working with cross functional teams
- Experience with various in vitro cell based assays including effector function activity, binding, internalization, proliferation, reporter cell assays,
- A background in independent critical thinking and scientific achievement
- Use of scientific databases and application for data management and data analysis (Graph Pad Prism, Soft Max Pro,, FlowJo etc)
LOCATION & TRAVEL REQUIREMENTS:
- This role is considered a hybrid position and you must be able to work onsite in Cambridge, MA on average 2-3 days per week.
WHAT TAKEDA CAN OFFER YOU: - 401(k) with company match and Annual Retirement Contribution Plan
- Tuition reimbursement Company match of charitable contributions
- Health & Wellness programs including onsite flu shots and health screenings
- Generous time off for vacation and the option to purchase additional vacation days
- Community Outreach Programs
Effective November 1, 2021, absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles..... click apply for full job details
