Postdoctoral Research Fellow – Genetic Code Expansion for Cell-based Imaging and Interaction Studies:
Merck USA

Merck USA
West Point Pennsylvania
Requisition ID: POS000251

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 

Be a part of the legacy: MRL Postdoctoral Research Fellow Program
The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview:

As a postdoctoral fellow in Merck Research Labs Chemical Biology group based in West Point, PA, you will work with a highly collaborative team of scientists to design and utilize novel methods for genetic code expansion to study intracellular protein interactions and dynamics.  This research will enable understanding the molecular mechanism of action for chemical probes with compelling phenotypes and provide insights on therapeutic strategies for pathways which have proven challenging to modulate clinically.

Responsibilities include but are not limited to:
  • Develop strategies and experiments based on genetic code expansion to address knowledge gaps in the understanding of disease biology
  • Design mutant proteins incorporating unnatural amino acids based on structural and functional data
  • Design constructs for co-expression of mutant proteins and orthogonal tRNA/aminoacyl-tRNA synthetase pairs; optimize expression efficiency
  • Design and conduct live cell imaging studies using a variety of techniques including but not limited to in-cell “click” reactions and confocal microscopy
  • Design and conduct cell-based interaction studies including photocrosslinking of proteins containing reactive unnatural amino acids, immunoprecipitation, digestion, protein mass spectrometry, and data analysis
  • Collaborate with Merck and external scientists including Chemical Biology, Structural Chemistry, Target Protein Design, Neuroscience, Pharmacology
  • Data interpretation, manuscript preparation, publication and presentation of results
  • Contribute to a safe and compliant laboratory work environment

Education Minimum Requirement:  
  • PhD with less than 3 years of Postdoctoral Experience or achieved a  Ph.D. by Spring/Summer of  2018 
Required Experience and Skills:
  • Ability to conceive, design, execute and communicate complex experiments in the field of genetic code expansion, as evidenced by publications
  • Molecular biology and protein expression optimization 
  • Cell imaging, WB, IP
  • Must be an independent and self-motivated scientist
Preferred Experience and Skills:
  • Proteostasis experience, signal transduction experience
  • Proteomics experience, bioinformatics experience
  • Optimization of bioorthogonal chemistry for cell-based applications

Our employees are the key to our company’s success.  We demonstrate our commitment to our employees by offering a competitive and valuable rewards program.  Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.
Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service


Job: Post-Doctoral Fellow
Other Locations:
Employee Status: Regular
Number of Openings:
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Company Trade Name: Merck
Basic Qualifications