Postdoctoral Research Fellow – Antibody Engineering:
Merck USA

Merck USA
Palo Alto California
Requisition ID: POS000234

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 

Be a part of the legacy: MRL Postdoctoral Research Fellow Program
The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview: 

As a postdoctoral fellow in Protein Sciences Antibody Engineering group based in Palo Alto, CA, you will work with a highly collaborative team of scientists that will combine rational-based protein engineering with structural and computational methods. This objective of this work will be to develop a technology platform that will enable optimization of next generation antibody therapeutics. 
Responsibilities include but are not limited to:

  • Design, construction, mammalian expression, and purification  of antibody molecules, antibody mutants, and antibody fragments
  • Conduct physicochemical experiments on antibodies using a variety of techniques (e.g. SEC, DSC, AC-SINS)
  • Collaborating with Merck and external scientists in structural, modeling, and molecular dynamics to validate models
  • Data interpretation, manuscript preparation, publication and presentation of results
  • Contribute to a safe and compliant laboratory work environment


Education Minimum Requirement:   
  • PhD with less than 3 years of Postdoctoral Experience or achieved a Ph.D. by Spring/Summer of  2018 
Required Experience and Skills: 
  • Experience with molecular biology, construct design, protein expression and purification, and analytical characterization of proteins 
  • Homology modeling and molecular dynamics
  • Ability to design, execute and communicate complex experiments in the field of computational biology, biophysics, and/or protein engineering
  • Must have strong organizational skills to deal with large amounts of data
  • Must be independent, self-motivated, and rigorous scientific logic
Preferred Experience and Skills: 
  • Experience with automation (e.g. TECAN) and HPLC systems
  • Structural biology experience
  • Programming or scripting experience

Our employees are the key to our company’s success.  We demonstrate our commitment to our employees by offering a competitive and valuable rewards program.  Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.
Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service


Job: Post-Doctoral Fellow
Other Locations:
Employee Status: Regular
Number of Openings:
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck
Basic Qualifications