Guidelines to In Vitro Skin Absorption Studies Training Course :

<strong>Course Schedule - Pre-recorded Course</strong><br/><br/>This 90-minute course will explain the importance of evaluating skin absorption of compounds from topically applied formulations for safety assessment and mechanistic studies prior to conducting clinical studies.<br><br> <b>Module 1:</b><br> <li>Rationale for assessment of skin penetration</li> <li>Regulatory parties involved:<br> – OECD<br> – CTFA<br> – WHO</li> <li>Description of general procedure</li><br><br> <b>Module 2:</b><br> <li>Preliminary required physical chemical properties</li> <li>Types of diffusion cells</li> <li>Finite and infinite dosing</li> <li>Importance of vehicle applied</li> <li>Fick’s first law for simple diffusion</li><br><br> <b>Module 3:</b><br> <li>Skin preparation:<br> – Choice of skin<br> – Species differences<br> – Preparation of tissue samples:<br> – Full thickness skin<br> – Epidermal skin<br> – Stratum corneum<br></li> </li>Testing skin barrier integrity</li> <li>Application of test compound</li> <li>Receptor fluid</li> <li>Evaluation of results</li> <li>Summary</li>