Biology Research Scientist:
Rgenta Therapeutics Inc.

1577870379
Rgenta Therapeutics Inc.
Woburn Massachusetts
Pharmaceutical
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Description
POSITION: Research Scientist - Target Biology & Therapeutic Discovery

Would you like to discover next-generation medicines? At Rgenta Therapeutics, we unlock the therapeutic potential of disease biology that is undruggable by traditional approaches. We have built proprietary RNA-targeting platforms that leverage our deep knowledge and innovative ideas in data-driven genomics, computational biology, high-throughput screening, and medicinal chemistry. Rgenta is a vibrant and exciting venture-backed start-up located in the Greater Boston area. Our efforts to develop new medicines demands a team of individuals with scientific curiosity, a can-do attitude, passion for progress, complementary skills, and thinking outside the box. Join us to discover new medicines and make scientific breakthroughs!

Rgenta's Target Biology group is currently seeking a motivated cell and molecular biologist to help the team launch new therapeutic discovery programs. This role will require leadership in both experiment design and execution to support novel therapeutic hypotheses. The successful candidate will have the opportunity to work with a multi-disciplinary team of scientists and be a key contributor to multiple stages of the drug discovery process. Efficient coordination of external collaborations and contract research will be an integral part of the overall leadership contributions. In addition to demonstrating the relevance of cellular factors to disease pathobiology, the position will involve creative assay development to enable the identification and characterization of pharmacological agents that modulate pre-mRNA processing.

ROLE RESPONSIBILITIES:
§ Integrate findings from our discovery platform, bioinformatics, literature, disease biology, and omics datasets to generate experimental strategies for drug target validation
§ Use a combination of cell, molecular, and biochemical techniques to demonstrate the validity of pharmacological strategies to modify disease pathology
§ Design, develop, and optimize biochemical and cell-based assays for in vitro pharmacology in high throughput formats
§ Build in vitro cellular and in vivo rodent models to demonstrate the safety and efficacy of drug candidate molecules undergoing medicinal chemistry optimization
§ Utilize functional genomic (CRISPR/cDNA screens) and chemical-biology techniques to identify the mechanism of action of drug candidates
§ Diligent maintenance of an electronic lab notebook in addition to presentation of research plans and datasets to company peers, senior management, board of directors, and scientific advisory board

BASIC QUALIFICATIONS:
§ MS or PhD degree in a biology or pharmacology related discipline, or equivalent industrial experience
§ Minimum 3-5 years of relevant research experience in the academic or pharmaceutical industry
§ Broad experience with molecular and cell biology experimental techniques (e.g. RT-qPCR, protein quantification, molecular cloning, ELISA, siRNA, shRNA, and CRISPR-based genome editing)
§ Understanding of with NGS-based genomic profiling techniques such as RNA-seq, ChIP- seq, and Amplicon-seq
§ Excellent communication and prior success in a collaborative, team-based research environment
§ Demonstrated learning agility and success moving into and mastering new or unfamiliar areas of science

DESIRED QUALIFICATIONS:
§ Past research involving RNA biology, pre-mRNA processing, and/or RNA-protein interactions
§ Experience developing and validating cell based or biochemical assays to support drug discovery, especially in oncology and neuroscience
§ Prior work in adapting experimental workflows to laboratory automation
§ Proficiency with basic bioinformatics tools such as RStudio

EEO & Employment Eligibility: Rgenta Therapeutics is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Rgenta Therapeutics also complies with all applicable federal, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Rgenta Therapeutics is an E-Verify employer.