Description
Position Title: Associate Scientist, Molecular Biology, Immuno-Oncology
Reports to: Scientist, Immuno-Oncology
Company Background:Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Century's genetically-engineered, universal iPSC-derived immune effector cell products are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer care.
Century's foundational technology is built on induced pluripotent stem cells (iPSCs) that have unlimited self-renewing capacity. This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. This platform differentiates Century from other approaches that utilize non-renewable donor-derived cells.
Role:We are seeking a highly motivated and creative associate scientist who is comfortable developing assays and working in a fast-paced environment. The ideal candidate will have significant experience in molecular biology. Specifically, isolation of nucleic acids, gel electrophoresis and imaging, PCR, qPCR, and ddPCR. Experience with Nanostring, RNA-Seq, and CRISPR technologies is preferred. The candidate will implement these techniques to help Century Therapeutics advance our universal iPSC-derived allogeneic cell products for targeting hematological and solid tumors. He/she will be responsible for utilizing existing resources as well as optimizing new protocols and technologies aimed to interrogate our CAR NK/T cell prototypes. The Associate Scientist will work closely and collaboratively with colleagues across different functional teams to achieve collective corporate goals. The perfect candidate will have a desire to learn new techniques and concepts through cross-functional training and collaboration.
Responsibilities:- Perform RNA and DNA isolations
- Design and carry out quantitative PCR experiments
- Analyze high-throughput datasets
- Present data in small and large group meetings
- Maintain specialized laboratory equipment
- Utilize the Nanostring platform
- Accurately record and document results in a timely, detailed, and organized manner
- Communicate clearly and effectively with team members and cross-functionally
- Requires occasional weekend work
Qualifications: BS or MS in a relevant biological or technical science with 5-7 years of relevant professional experience.
Requirements: Essential
- Ability to work in a fast-paced environment, adapt to changes, and learn quickly
- Strong communication skills and a good team player
- Strong organizational skills
- Understanding of molecular biology concepts
- Extensive experience with molecular biology lab techniques including isolation of nucleic acids, electrophoresis, and PCR
- Ability to perform and analyze complex experiments
- Strong proficiency in Excel, Prism, Spotfire, or other data analysis software
- Desire to learn about immunology and the field of iPSC-derived CAR immune cells
Preferred
- Experience performing qPCR and ddPCR
- Experience with Nanostring or RNA-Seq, especially single cell RNA-Seq
- Experience with primary (immune) cells is a plus
- Flow cytometry experience is a plus
Century Therapeutics Inc. is an Equal Employment Opportunity/Affirmative Action Employer - Minority/Female/Disability/Veteran. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or veteran status or any other characteristic protected by federal, state, or local law.