Associate Research Scientist - Cryo - SIGN ON BONUS $1,000:
Charles River Laboratories, Inc.

Charles River Laboratories, Inc.
Durham North Carolina

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

Basic job summary: 
Will be the Team Leader responsible for the technical and functional oversight of the Cryo-Electron Microscopy lab, which includes a 200kV transmission electron microscope (JEOL JEM-2100+) and associated equipment in the adjacent BSL-2 laboratory.  

•    Oversee the upfit and implementation of the lab and ensure that all systems are in place to receive BSL-2 samples, perform BSL-2 studies, and maintain a BSL-2 lab with all appropriate documentation.
•    Work closely with Client Services to meet and provide information to Sponsors, to initiate studies, and to provide on-time deliverables.
•    Collaborate with the System Administrator to validate the imaging software of the microscope in order to perform GLP studies.
•    Act as the Study Director for studies.
•    Receive unfixed samples, prepare cryo preps of samples, image samples on the cryo-EM, interpret results, and prepare reports for the sponsor.
•    Train current EM staff on the preparation and scoping of cryo-EM samples.
•    Maintain and perform routine maintenance of the microscope (e.g., changing LaB6 filament) and other laboratory equipment.
•    Perform other Electron Microscopy and laboratory tasks.  
•    Assist management in promoting the service through marketing initiatives, and actively participate in strategy regarding future EM initiatives and capabilities

Job Qualifications

•    The position requires an expert scientist with a deep theoretical and technical understanding of cryo-EM, and related experience in the preparation, scoping, and analysis of Adeno-associated virus (AAV).  
•    Education: BS or equivalent in biology or related discipline. Related Master's degree (M.S./M.A.) or PhD/DVM preferred.
•    Experience: Minimum of 5 year related experience in Cryo Electron Microscopy
•    An equivalent combination of education and experience may be accepted. 
•    Other: Placement at this level requires successful completion/competency of the required tasks preceding this level and continued ability to perform those task required.   Must be able to perform effectively as a team member, accurately record data, follow verbal and written instructions, maintain a positive work atmosphere, communicate effectively, and interact in a professional manner.    Able to work independently. 

About Safety Assessment
Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market.  Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities.


About Charles River
Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.


With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.


At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~85% of the drugs approved by the FDA in 2019.


Equal Employment Opportunity

Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.


If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to [email protected] This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.


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