2018 MRL Immunology Oncology Intern:

Palo Alto California
Requisition ID: ADM009175

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 

The Future Talent Program features internships that last 9-12weeks and the Early Development and Discovery Sciences Department has an internshipwithin Immuno-Oncology Discovery Research in Palo Alto, CA.


T cell populations contain T cells with different antigenspecificities, maturation stage and expression of co-stimulatory orco-inhibitory immune regulatory receptors (IMR).   Therefore it isdifficult to predict T cell responsiveness and outcome of interactions of IMR’s and their ligands at the population level. Establishment of T cell clonesdoes provide an opportunity to study IMR biology in a physiological manner atthe single cell level.  T cell clones have been established againstallo-antigens expressed on antigen presenting cells (APC) such as EBVtransformed B cells and Melanoma cells. These APC have been modified to expressIMR ligands such as PD-L1, CD155 or both.  The characteristics of these Tcells with respect to function (proliferation, cytotoxicity, cytokineproduction) and phenotype as well as responsiveness to IMR manipulation on APCwill be studied in in vitro experiments using a number of cellular immunologytechniques.


The primary duties of this internship will involvecharacterization of human T cell clone function by immune checkpointinhibition. The selected candidate will study the role of immune checkpointinhibitors on human T cell function and ways to increase anti-tumorresponses.  Experience will be obtained in cell isolation, T cell culture,FACS analyses, ELISA and PCR techniques.  



  • Candidates muse be currently enrolled in a minimum of a BS/BA in:Biology, Biochemistry, Chemistry or relevant discipline
  • Minimum GPA of 3.0
Required Experience:
  • Candidates must be available for a period of 9-12 continuousweeks, beginning June 2018
Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. 


If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to staffingaadar@merck.com.


Search Firm Representatives Please Read Carefully: 

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.


Visa sponsorship is not available for this position.


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FTP 2018

Job: Administrative Svcs Generic
Other Locations:
Employee Status: Temporary
Travel: No
Number of Openings:
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck
Basic Qualifications