Description
(Principal) Research Associate, Molecular Biology - Waltham, MA
About Alloy Therapeutics
Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners across academia, biotech, and the largest biopharma, Alloy democratizes access to tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. Alloy's foundational technology, the ATX-Gx™️, is a human therapeutic antibody discovery platform consisting of a growing suite of proprietary transgenic mice strains. Alloy is a leader in bispecific antibody discovery and engineering services, utilizing its proprietary ATX-CLC common light chain platform integrating novel transgenic mice and phage display. DeepImmune™️ integrates Alloy's full complement of proprietary in vivo, in vitro, and in silico discovery and optimization technologies into one comprehensive offering for fully human antibody, bispecific, and TCR discovery. DeepImmune is also available for royalty-free access as part of Alloy's novel Innovation Subscription model. Alloy is headquartered in Boston, MA with labs in Cambridge, UK; Basel, CH; San Francisco, CA; and Athens, GA. As a reflection of Alloy's relentless commitment to the scientific community, Alloy reinvests 100% of its revenue in innovation and access to innovation.
About (Principal) Research Associate, Molecular Biology- Waltham, MA
Our Alloy Discovery Services group is looking for a (Principal) Research Associate, Molecular Biology to join our team in Waltham, Massachusetts. The position will report directly to our Head of Molecular Biology and work with our Antibody Discovery Services team to support the discovery of antibody-based therapeutics and help strengthen and develop our internal platform technologies at Alloy. You will be using and helping to develop the latest in cellular and molecular biology techniques, protocols, and automation for the ultimate goal of making better medicines together with our collaborators.
Principal Responsibilities
• Perform recombinant DNA activities, ranging from cloning (Gibson Assembly, PCR, Vector Digestion) and DNA plasmid purification (small & large-scale) to supporting antigen, antibody and multi-specific molecule construction and production
• Utilize high-throughput workflow methodology and automation to accomplish recombinant DNA production and assembly
• Analyze and interpret DNA sequencing results and maintain analysis output and results tracking
• Support Antibody Discovery Services projects, by performing B cell cloning & and hybridoma workflow and sequence recovery
• Help coordinate small- and large-scale DNA hand-off between function groups
• Catalog and maintain internal reagents and Molecular Biology output
• Maintain organized electronic Lab Notebook & utilize electronic LIMs system for DNA and Protein sample tracking
• Be generous when others are needy, greedy or fearful
Required Qualifications and Skills
• MS with 1+ year or BS/BA with 3+ years of research experience working with recombinant DNA in support of discovery of biologics
• BA/BS/MS in an appropriate scientific discipline (immunology, cellular or molecular biology)
• Experience with protein expression vectors design and cloning methodologies
• Familiarity with antibody expression vectors including monoclonal and bispecific constructs
• Demonstrated experience with high-throughput production and characterization methods and equipment
• Experience using DNA sequence analysis software is a plus
• Willingness to learn and grow in a dynamic team setting
• Attention to detail, rigorous scientific thinking and appropriate documentation, clear
communication skills
• A sense of urgency, speed, persistence, and organization in a dynamic, fun, and exciting work environment
Benefits Include
• Competitive base salary based on the position and your experience level
• Significant opportunities for career advancement and mentorship inside Alloy, through our affiliated venture studio that creates new companies every year, and across our network of over 100 affiliated and partner companies
• Generous equity compensation in a company with incredible growth potential and a 30+ year plan
• Generous personal and family medical, dental and vision benefits with 90% of premiums and deductibles covered by Alloy, company-paid disability insurance, and an annual stipend for continuing education
• Flexible schedule, unlimited vacation as long as the job gets done, medical leave including time caring for sick family members, and parental leave all built around our team-driven philosophy
• Commitment to your career through individualized professional development plan for all employees to ensure good role and skill fit either at Alloy or your next biotech company
• Additional benefits including adoption support over $40,000, IVF/PGT support, compensated time for bone marrow donation, continuing education, leadership development and others
