Description
The course will provide participants with an understanding of the principals and fundamentals for absorption, distribution, metabolism, and the elimination (ADME) of pharmaceutical chemicals. The actual dose of a drug that ultimately reaches the target tissues and exerts pharmacologic or toxicologic effects is highly dependent on the kinetics of drug absorption and disposition in the body. Many factors can influence these kinetic processes. The goal of the course is to provide training in the fundamentals of ADME that should be understood for those involved in drug development and clinical applications. The thrust of the discussions will pertain to drugs, although the concepts are appropriate for all chemical entities. Some modeling and mathematical formulations will be presented; however, the lack of mathematical background will not impede one’s ability to understand the concepts involved. Finally, a few practical examples of the ADME of drugs will be provided to illustrate how the principles are applied in real life situations.
